Detection of human papilloma virus genome in laryngeal carcinomas by Talaat Iman

Description: Detection of human papilloma virus genome in laryngeal carcinomas by Talaat Iman Mamdouh, Helal Suzan, El-Tawil Galila Human papilloma viruses (HPV) have been implicated in the genesis of several human cancers, including squamous tumors of the upper respiratory tract. Although it is known that tobacco and alcohol are the main causal agents, epidemiologic and molecular studies have suggested a role for HPV infection in the pathogenesis of laryngeal tumors. Despite the large number of reports about HPV prevalence in these anatomical regions, the role of HPV in the development of squamous cell carcinoma of the larynx is poorly understood. In benign lesions caused by HPV, viral DNA is located extrachromosomally in the nuclei of infected cells, it remains episomal (free) whereas it is integrated into host chromosomal DNA in malignant cells. Various techniques exist for the detection and typing of HPV DNA. They are all based on demonstration, under controlled conditions, of the ability of the nucleic acid being tested to reassociate with a probe. Recently, the in situ hybridization technique (ISH) and the polymerase chain reaction (PCR) are the methods of choice. FORMAT Paperback LANGUAGE English CONDITION Brand New Long Description Human papilloma viruses (HPV) have been implicated in the genesis of several human cancers, including squamous tumors of the upper respiratory tract. Although it is known that tobacco and alcohol are the main causal agents, epidemiologic and molecular studies have suggested a role for HPV infection in the pathogenesis of laryngeal tumors. Despite the large number of reports about HPV prevalence in these anatomical regions, the role of HPV in the development of squamous cell carcinoma of the larynx is poorly understood. In benign lesions caused by HPV, viral DNA is located extrachromosomally in the nuclei of infected cells, it remains episomal (free) whereas it is integrated into host chromosomal DNA in malignant cells. Various techniques exist for the detection and typing of HPV DNA. They are all based on demonstration, under controlled conditions, of the ability of the nucleic acid being tested to reassociate with a probe. Recently, the in situ hybridization technique (ISH) and the polymerase chain reaction (PCR) are the methods of choice. Details ISBN3659661244 Author El-Tawil Galila Pages 164 Year 2014 ISBN-10 3659661244 ISBN-13 9783659661242 Publication Date 2014-12-17 Short Title DETECTION OF HUMAN PAPILLOMA V Language English Media Book Format Paperback UK Release Date 2014-12-17 Imprint LAP Lambert Academic Publishing Illustrations Illustrations, black and white Publisher LAP Lambert Academic Publishing Audience General We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:132479711;

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